藥物交互作用
Atazanavir + Pantoprazole
嚴重程度: 嚴重
Atazanavir and Pantoprazole: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Atazanavir needs an acidic environment for dissolution, and pantoprazole markedly reduces its absorption. This can lead to subtherapeutic antiretroviral levels, virologic failure and resistance.
用白話說明這項交互作用的意義
Atazanavir and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Pantoprazole belongs to Gastrointestinal Tract.
為什麼會發生
Elevated gastric pH reduces atazanavir solubility and oral absorption.
處置方式
Avoid in treatment-experienced patients; in treatment-naive patients follow labeling with ritonavir boosting, limited PPI dose and staggered timing, with virologic monitoring.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pantoprazole 的其他交互作用
Atazanavir 的其他交互作用
常見問題
Can I take Atazanavir with Pantoprazole?
MediHelp rates the interaction as major. Atazanavir and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir needs an acidic environment for dissolution, and pantoprazole markedly reduces its absorption. This can lead to subtherapeutic antiretroviral levels, virologic failure and resistance.
How serious is the interaction between Atazanavir and Pantoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in treatment-experienced patients; in treatment-naive patients follow labeling with ritonavir boosting, limited PPI dose and staggered timing, with virologic monitoring.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Dacomitinib. The full list is on the Pantoprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
