藥物交互作用
Erlotinib + Pantoprazole
嚴重程度: 嚴重
Erlotinib and Pantoprazole: major interaction.
最後更新
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摘要
Erlotinib dissolves best at low gastric pH, and pantoprazole suppresses gastric acid so much that erlotinib absorption falls substantially (AUC reduction of about half with omeprazole). Tumour exposure may be inadequate.
用白話說明這項交互作用的意義
Erlotinib and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erlotinib belongs to Oncology; Pantoprazole belongs to Gastrointestinal Tract.
為什麼會發生
Raised gastric pH reduces erlotinib solubility and absorption
處置方式
Avoid PPIs; if acid suppression is needed, give erlotinib 2 hours before or 10 hours after an H2 antagonist, or use antacids separated by several hours.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Erlotinib 的其他交互作用
Pantoprazole 的其他交互作用
常見問題
Can I take Erlotinib with Pantoprazole?
MediHelp rates the interaction as major. Erlotinib and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erlotinib dissolves best at low gastric pH, and pantoprazole suppresses gastric acid so much that erlotinib absorption falls substantially (AUC reduction of about half with omeprazole). Tumour exposure may be inadequate.
How serious is the interaction between Erlotinib and Pantoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs; if acid suppression is needed, give erlotinib 2 hours before or 10 hours after an H2 antagonist, or use antacids separated by several hours.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
