藥物交互作用
Dacomitinib + Pantoprazole
嚴重程度: 嚴重
Dacomitinib and Pantoprazole: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Proton pump inhibitors reduce dacomitinib exposure, which may lessen its antitumor efficacy. The effect stems from reduced absorption at higher gastric pH.
用白話說明這項交互作用的意義
Dacomitinib and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Pantoprazole belongs to Gastrointestinal Tract.
為什麼會發生
Higher gastric pH from the proton pump inhibitor reduces dacomitinib solubility and absorption.
處置方式
Avoid pantoprazole; if acid suppression is needed, use a locally acting antacid or an H2 blocker with dacomitinib given at least 6 hours before or 10 hours after.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pantoprazole 的其他交互作用
Dacomitinib 的其他交互作用
常見問題
Can I take Dacomitinib with Pantoprazole?
MediHelp rates the interaction as major. Dacomitinib and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Proton pump inhibitors reduce dacomitinib exposure, which may lessen its antitumor efficacy. The effect stems from reduced absorption at higher gastric pH.
How serious is the interaction between Dacomitinib and Pantoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pantoprazole; if acid suppression is needed, use a locally acting antacid or an H2 blocker with dacomitinib given at least 6 hours before or 10 hours after.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
