藥物交互作用
Aceclofenac + Probenecid
嚴重程度: 中度
Aceclofenac and Probenecid: moderate interaction.
最後更新
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摘要
Probenecid inhibits renal organic anion transport and can raise NSAID concentrations, including those of aceclofenac and its metabolites. This may increase NSAID adverse effects such as gastrointestinal and renal toxicity.
用白話說明這項交互作用的意義
Aceclofenac and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aceclofenac belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
為什麼會發生
Probenecid inhibits OAT-mediated renal tubular secretion of aceclofenac and its metabolites.
處置方式
Use the lowest effective aceclofenac dose and monitor for GI bleeding and renal function. Reduce the NSAID dose if adverse effects appear.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Probenecid 的其他交互作用
Aceclofenac 的其他交互作用
常見問題
Can I take Aceclofenac with Probenecid?
MediHelp rates the interaction as moderate. Aceclofenac and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid inhibits renal organic anion transport and can raise NSAID concentrations, including those of aceclofenac and its metabolites. This may increase NSAID adverse effects such as gastrointestinal and renal toxicity.
How serious is the interaction between Aceclofenac and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective aceclofenac dose and monitor for GI bleeding and renal function. Reduce the NSAID dose if adverse effects appear.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
