藥物交互作用
Baricitinib + Probenecid
嚴重程度: 嚴重
Baricitinib and Probenecid: major interaction.
最後更新
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摘要
Probenecid inhibits renal organic anion transporter 3, which helps clear baricitinib into urine. Baricitinib exposure rises, which may increase dose-related adverse effects such as infection, cytopenias and lipid changes.
用白話說明這項交互作用的意義
Baricitinib and Probenecid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baricitinib belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
為什麼會發生
Inhibition of OAT3-mediated renal tubular secretion of baricitinib reduces its elimination.
處置方式
Baricitinib labeling advises against using it with strong OAT3 inhibitors such as probenecid; if unavoidable, reduce the baricitinib dose as per labeling. Monitor for infection and hematologic abnormalities.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Probenecid 的其他交互作用
Baricitinib 的其他交互作用
常見問題
Can I take Baricitinib with Probenecid?
MediHelp rates the interaction as major. Baricitinib and Probenecid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Probenecid inhibits renal organic anion transporter 3, which helps clear baricitinib into urine. Baricitinib exposure rises, which may increase dose-related adverse effects such as infection, cytopenias and lipid changes.
How serious is the interaction between Baricitinib and Probenecid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Baricitinib labeling advises against using it with strong OAT3 inhibitors such as probenecid; if unavoidable, reduce the baricitinib dose as per labeling. Monitor for infection and hematologic abnormalities.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Ceftazidime / avibactam. The full list is on the Probenecid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
