藥物交互作用
Pralatrexate + Probenecid
嚴重程度: 嚴重
Pralatrexate and Probenecid: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Probenecid can reduce the renal clearance of pralatrexate, increasing exposure and the risk of toxicities such as mucositis and myelosuppression.
用白話說明這項交互作用的意義
Pralatrexate and Probenecid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pralatrexate belongs to Oncology; Probenecid belongs to Genitourinary.
為什麼會發生
Probenecid inhibits the renal tubular secretion of pralatrexate via organic anion transporters.
處置方式
Avoid concurrent use if possible. If it is necessary, monitor closely for mucositis and cytopenias and consider holding or reducing pralatrexate per labeling.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Probenecid 的其他交互作用
Pralatrexate 的其他交互作用
常見問題
Can I take Pralatrexate with Probenecid?
MediHelp rates the interaction as major. Pralatrexate and Probenecid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Probenecid can reduce the renal clearance of pralatrexate, increasing exposure and the risk of toxicities such as mucositis and myelosuppression.
How serious is the interaction between Pralatrexate and Probenecid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible. If it is necessary, monitor closely for mucositis and cytopenias and consider holding or reducing pralatrexate per labeling.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
