藥物交互作用
Ceftazidime / avibactam + Probenecid
嚴重程度: 嚴重
Ceftazidime / avibactam and Probenecid: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Probenecid inhibits renal OAT-mediated uptake of avibactam, which can reduce its elimination and increase exposure. Labeling advises against coadministration.
用白話說明這項交互作用的意義
Ceftazidime / avibactam and Probenecid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Probenecid inhibits OAT1/OAT3-mediated renal tubular uptake and secretion of avibactam.
處置方式
Avoid coadministration; use an alternative to probenecid where possible.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Probenecid 的其他交互作用
常見問題
Can I take Ceftazidime / avibactam with Probenecid?
MediHelp rates the interaction as major. Ceftazidime / avibactam and Probenecid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Probenecid inhibits renal OAT-mediated uptake of avibactam, which can reduce its elimination and increase exposure. Labeling advises against coadministration.
How serious is the interaction between Ceftazidime / avibactam and Probenecid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; use an alternative to probenecid where possible.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
