藥物交互作用
Acemetacin + Probenecid
嚴重程度: 中度
Acemetacin and Probenecid: moderate interaction.
最後更新
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摘要
Probenecid reduces the renal tubular secretion of indometacin, the active metabolite of acemetacin, raising its levels. This can increase NSAID adverse effects such as GI bleeding and renal impairment.
用白話說明這項交互作用的意義
Acemetacin and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Probenecid inhibits OAT-mediated renal tubular secretion of acemetacin and its active metabolite indometacin.
處置方式
Monitor for NSAID toxicity (GI symptoms, renal function) and use the lowest effective acemetacin dose.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Probenecid 的其他交互作用
常見問題
Can I take Acemetacin with Probenecid?
MediHelp rates the interaction as moderate. Acemetacin and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces the renal tubular secretion of indometacin, the active metabolite of acemetacin, raising its levels. This can increase NSAID adverse effects such as GI bleeding and renal impairment.
How serious is the interaction between Acemetacin and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID toxicity (GI symptoms, renal function) and use the lowest effective acemetacin dose.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
