藥物交互作用
Acetylsalicylic acid + Ticagrelor
嚴重程度: 嚴重
Acetylsalicylic acid and Ticagrelor: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Maintenance aspirin doses above 100 mg daily reduce the clinical benefit of ticagrelor, with worse cardiovascular outcomes seen. The combination is standard with low-dose aspirin, but bleeding risk is additive.
用白話說明這項交互作用的意義
Acetylsalicylic acid and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Ticagrelor belongs to Cardiovascular.
為什麼會發生
Additive platelet inhibition increases bleeding, and higher aspirin doses appear to diminish ticagrelor efficacy through a mechanism that is not fully understood.
處置方式
Keep maintenance aspirin at 75-100 mg daily after any initial loading dose. Monitor for bleeding.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Acetylsalicylic acid 的其他交互作用
Ticagrelor 的其他交互作用
常見問題
Can I take Acetylsalicylic acid with Ticagrelor?
MediHelp rates the interaction as major. Acetylsalicylic acid and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Maintenance aspirin doses above 100 mg daily reduce the clinical benefit of ticagrelor, with worse cardiovascular outcomes seen. The combination is standard with low-dose aspirin, but bleeding risk is additive.
How serious is the interaction between Acetylsalicylic acid and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep maintenance aspirin at 75-100 mg daily after any initial loading dose. Monitor for bleeding.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
