藥物交互作用
Levoketoconazole + Ticagrelor
嚴重程度: 禁忌併用
Levoketoconazole and Ticagrelor: contraindicated interaction.
最後更新
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摘要
Levoketoconazole is a strong CYP3A inhibitor and is expected to markedly increase ticagrelor exposure, raising bleeding risk. Strong CYP3A inhibitors such as ketoconazole are not recommended with ticagrelor.
用白話說明這項交互作用的意義
Levoketoconazole and Ticagrelor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Ticagrelor belongs to Cardiovascular.
為什麼會發生
Strong CYP3A4 inhibition reduces ticagrelor clearance.
處置方式
Avoid the combination and choose an alternative antiplatelet. If antifungal or cortisol-lowering therapy is needed, consider an option without strong CYP3A inhibition.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ticagrelor 的其他交互作用
Levoketoconazole 的其他交互作用
常見問題
Can I take Levoketoconazole with Ticagrelor?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Ticagrelor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A inhibitor and is expected to markedly increase ticagrelor exposure, raising bleeding risk. Strong CYP3A inhibitors such as ketoconazole are not recommended with ticagrelor.
How serious is the interaction between Levoketoconazole and Ticagrelor?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antiplatelet. If antifungal or cortisol-lowering therapy is needed, consider an option without strong CYP3A inhibition.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Abciximab. The full list is on the Ticagrelor page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
