藥物交互作用
Adenovirus types 4 and 7 live + Cladribine
嚴重程度: 禁忌併用
Adenovirus types 4 and 7 live and Cladribine: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cladribine causes prolonged lymphopenia and immunosuppression. The live oral adenovirus vaccine could replicate unchecked and cause vaccine-related infection, and the vaccine response may be poor.
用白話說明這項交互作用的意義
Adenovirus types 4 and 7 live and Cladribine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Cladribine-induced lymphocyte depletion impairs immunity, allowing live attenuated virus replication and reducing vaccine efficacy.
處置方式
Do not give live vaccines during cladribine treatment or while lymphocyte counts remain low after it. Vaccinate at least 4 to 6 weeks before starting cladribine, and check lymphocyte recovery before any later live vaccine.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Cladribine 的其他交互作用
常見問題
Can I take Adenovirus types 4 and 7 live with Cladribine?
MediHelp rates the interaction as contraindicated. Adenovirus types 4 and 7 live and Cladribine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cladribine causes prolonged lymphopenia and immunosuppression. The live oral adenovirus vaccine could replicate unchecked and cause vaccine-related infection, and the vaccine response may be poor.
How serious is the interaction between Adenovirus types 4 and 7 live and Cladribine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines during cladribine treatment or while lymphocyte counts remain low after it. Vaccinate at least 4 to 6 weeks before starting cladribine, and check lymphocyte recovery before any later live vaccine.
What other medicines interact with Cladribine?
MediHelp also lists interactions of Cladribine with, for example, Siponimod, Tofacitinib, Axicabtagene ciloleucel. The full list is on the Cladribine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
