藥物交互作用
Axicabtagene ciloleucel + Cladribine
嚴重程度: 嚴重
Axicabtagene ciloleucel and Cladribine: major interaction.
最後更新
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摘要
Cladribine is toxic to lymphocytes and may impair collection or expansion of T cells, and may reduce CAR-T cell function and persistence. The combination also adds to immunosuppression and infection risk.
用白話說明這項交互作用的意義
Axicabtagene ciloleucel and Cladribine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Cladribine belongs to Oncology.
為什麼會發生
Lymphotoxic effect of cladribine reduces T-cell numbers and function, affecting CAR-T manufacturing and expansion, and adds to immunosuppression.
處置方式
Avoid cladribine in the period before leukapheresis and CAR-T infusion; follow the product labeling for the washout interval. Monitor closely for infections if exposure has occurred.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cladribine 的其他交互作用
Axicabtagene ciloleucel 的其他交互作用
常見問題
Can I take Axicabtagene ciloleucel with Cladribine?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Cladribine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cladribine is toxic to lymphocytes and may impair collection or expansion of T cells, and may reduce CAR-T cell function and persistence. The combination also adds to immunosuppression and infection risk.
How serious is the interaction between Axicabtagene ciloleucel and Cladribine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cladribine in the period before leukapheresis and CAR-T infusion; follow the product labeling for the washout interval. Monitor closely for infections if exposure has occurred.
What other medicines interact with Cladribine?
MediHelp also lists interactions of Cladribine with, for example, Adenovirus types 4 and 7 live, Siponimod, Tofacitinib. The full list is on the Cladribine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
