藥物交互作用
Cholera vaccine + Cladribine
嚴重程度: 嚴重
Cholera vaccine and Cladribine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cladribine causes prolonged lymphocyte depletion, which can reduce the immune response to vaccines. The oral cholera vaccine is live attenuated, so there is also a theoretical risk of infection from the vaccine strain.
用白話說明這項交互作用的意義
Cholera vaccine and Cladribine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Cladribine-induced lymphopenia impairs vaccine immune responses and may permit replication of a live attenuated vaccine strain.
處置方式
Avoid live vaccines during and after cladribine until lymphocyte counts have recovered. Where possible, complete vaccination at least 4 to 6 weeks before starting cladribine.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cladribine 的其他交互作用
常見問題
Can I take Cholera vaccine with Cladribine?
MediHelp rates the interaction as major. Cholera vaccine and Cladribine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cladribine causes prolonged lymphocyte depletion, which can reduce the immune response to vaccines. The oral cholera vaccine is live attenuated, so there is also a theoretical risk of infection from the vaccine strain.
How serious is the interaction between Cholera vaccine and Cladribine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during and after cladribine until lymphocyte counts have recovered. Where possible, complete vaccination at least 4 to 6 weeks before starting cladribine.
What other medicines interact with Cladribine?
MediHelp also lists interactions of Cladribine with, for example, Adenovirus types 4 and 7 live, Siponimod, Tofacitinib. The full list is on the Cladribine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
