藥物交互作用
Adenovirus types 4 and 7 live + Fludarabine
嚴重程度: 禁忌併用
Adenovirus types 4 and 7 live and Fludarabine: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Fludarabine causes profound and prolonged lymphopenia. A live oral adenovirus vaccine could replicate unchecked and cause disseminated vaccine-strain infection, and the vaccine response would also be poor.
用白話說明這項交互作用的意義
Adenovirus types 4 and 7 live and Fludarabine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Fludarabine-induced immunosuppression impairs control of live attenuated virus replication and reduces vaccine immunogenicity.
處置方式
Do not give this live vaccine during fludarabine therapy. Defer vaccination until immune recovery is confirmed, usually at least 3 months after therapy ends.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Fludarabine 的其他交互作用
常見問題
Can I take Adenovirus types 4 and 7 live with Fludarabine?
MediHelp rates the interaction as contraindicated. Adenovirus types 4 and 7 live and Fludarabine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fludarabine causes profound and prolonged lymphopenia. A live oral adenovirus vaccine could replicate unchecked and cause disseminated vaccine-strain infection, and the vaccine response would also be poor.
How serious is the interaction between Adenovirus types 4 and 7 live and Fludarabine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give this live vaccine during fludarabine therapy. Defer vaccination until immune recovery is confirmed, usually at least 3 months after therapy ends.
What other medicines interact with Fludarabine?
MediHelp also lists interactions of Fludarabine with, for example, Pentostatin, Belatacept, Dengue vaccine. The full list is on the Fludarabine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
