藥物交互作用
Etrasimod + Fludarabine
嚴重程度: 嚴重
Etrasimod and Fludarabine: major interaction.
最後更新
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摘要
Etrasimod lowers circulating lymphocytes by sequestering them in lymphoid tissue, and fludarabine causes marked lymphopenia. Together they could cause additive immunosuppression and serious infection, and the combination has not been studied.
用白話說明這項交互作用的意義
Etrasimod and Fludarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Fludarabine belongs to Oncology.
為什麼會發生
Additive lymphocyte reduction: S1P receptor modulation with purine analog cytotoxicity.
處置方式
Avoid combining them, and allow an adequate interval after stopping etrasimod before starting fludarabine. If unavoidable, monitor lymphocyte counts and for infection.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fludarabine 的其他交互作用
Etrasimod 的其他交互作用
常見問題
Can I take Etrasimod with Fludarabine?
MediHelp rates the interaction as major. Etrasimod and Fludarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes by sequestering them in lymphoid tissue, and fludarabine causes marked lymphopenia. Together they could cause additive immunosuppression and serious infection, and the combination has not been studied.
How serious is the interaction between Etrasimod and Fludarabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them, and allow an adequate interval after stopping etrasimod before starting fludarabine. If unavoidable, monitor lymphocyte counts and for infection.
What other medicines interact with Fludarabine?
MediHelp also lists interactions of Fludarabine with, for example, Adenovirus types 4 and 7 live, Pentostatin, Belatacept. The full list is on the Fludarabine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
