藥物交互作用
Fludarabine + Pentostatin
嚴重程度: 禁忌併用
Fludarabine and Pentostatin: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Combining these purine analogues has caused severe or fatal pulmonary toxicity in clinical use. The combination is contraindicated in labeling.
用白話說明這項交互作用的意義
Fludarabine and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fludarabine belongs to Oncology; Pentostatin belongs to Oncology.
為什麼會發生
The mechanism is not established, though additive purine analogue toxicity, possibly involving adenosine deaminase inhibition, is suspected.
處置方式
Do not use together; choose a different regimen. Observe patients for respiratory symptoms if previously exposed.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Fludarabine 的其他交互作用
Pentostatin 的其他交互作用
常見問題
Can I take Fludarabine with Pentostatin?
MediHelp rates the interaction as contraindicated. Fludarabine and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining these purine analogues has caused severe or fatal pulmonary toxicity in clinical use. The combination is contraindicated in labeling.
How serious is the interaction between Fludarabine and Pentostatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a different regimen. Observe patients for respiratory symptoms if previously exposed.
What other medicines interact with Fludarabine?
MediHelp also lists interactions of Fludarabine with, for example, Adenovirus types 4 and 7 live, Belatacept, Dengue vaccine. The full list is on the Fludarabine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
