藥物交互作用
Fingolimod + Fludarabine
嚴重程度: 嚴重
Fingolimod and Fludarabine: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Fludarabine causes profound and prolonged lymphopenia and myelosuppression. Combined with fingolimod, the risk of serious infection is increased.
用白話說明這項交互作用的意義
Fingolimod and Fludarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Fludarabine belongs to Oncology.
為什麼會發生
Additive lymphocyte depletion from purine analog cytotoxicity and fingolimod sequestration.
處置方式
Avoid concurrent use where possible. Monitor lymphocyte counts and infection signs, and consider stopping fingolimod before fludarabine.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fingolimod 的其他交互作用
Fludarabine 的其他交互作用
常見問題
Can I take Fingolimod with Fludarabine?
MediHelp rates the interaction as major. Fingolimod and Fludarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fludarabine causes profound and prolonged lymphopenia and myelosuppression. Combined with fingolimod, the risk of serious infection is increased.
How serious is the interaction between Fingolimod and Fludarabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. Monitor lymphocyte counts and infection signs, and consider stopping fingolimod before fludarabine.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
