藥物交互作用
Adenovirus types 4 and 7 live + Irinotecan
嚴重程度: 嚴重
Adenovirus types 4 and 7 live and Irinotecan: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Irinotecan is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may replicate excessively or fail to provoke adequate immunity. This raises the risk of vaccine-related infection and reduced protection.
用白話說明這項交互作用的意義
Adenovirus types 4 and 7 live and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Cytotoxic immunosuppression impairs the immune response to live attenuated virus, allowing uncontrolled replication and reducing vaccine efficacy.
處置方式
Avoid live vaccines during irinotecan therapy and for at least 3 months after stopping, unless the immune status is confirmed to have recovered. Give vaccines before starting chemotherapy where possible.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Irinotecan 的其他交互作用
常見問題
Can I take Adenovirus types 4 and 7 live with Irinotecan?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Irinotecan is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may replicate excessively or fail to provoke adequate immunity. This raises the risk of vaccine-related infection and reduced protection.
How serious is the interaction between Adenovirus types 4 and 7 live and Irinotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during irinotecan therapy and for at least 3 months after stopping, unless the immune status is confirmed to have recovered. Give vaccines before starting chemotherapy where possible.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Apalutamide. The full list is on the Irinotecan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
