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藥物交互作用

Irinotecan + Sacituzumab govitecan

嚴重程度: 禁忌併用

Irinotecan and Sacituzumab govitecan: contraindicated interaction.

最後更新

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Sacituzumab govitecan delivers SN-38, the active metabolite of irinotecan, so combining the two duplicates exposure to the same cytotoxic agent. This can increase severe neutropenia and diarrhea.

用白話說明這項交互作用的意義

Irinotecan and Sacituzumab govitecan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Irinotecan belongs to Oncology; Sacituzumab govitecan belongs to Oncology.

證據等級: Moderate

為什麼會發生

Duplicate delivery of SN-38, a topoisomerase I inhibitor, producing additive toxicity.

處置方式

Do not use these drugs together or substitute one for the other.

可向藥師詢問的問題

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Irinotecan 與 Sacituzumab govitecan 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Irinotecan with Sacituzumab govitecan?

MediHelp rates the interaction as contraindicated. Irinotecan and Sacituzumab govitecan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sacituzumab govitecan delivers SN-38, the active metabolite of irinotecan, so combining the two duplicates exposure to the same cytotoxic agent. This can increase severe neutropenia and diarrhea.

How serious is the interaction between Irinotecan and Sacituzumab govitecan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use these drugs together or substitute one for the other.

What other medicines interact with Sacituzumab govitecan?

MediHelp also lists interactions of Sacituzumab govitecan with, for example, Siponimod. The full list is on the Sacituzumab govitecan page.

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