藥物交互作用
Carbamazepine + Irinotecan
嚴重程度: 嚴重
Carbamazepine and Irinotecan: major interaction.
最後更新
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摘要
Carbamazepine is a strong inducer of CYP3A4, CYP2B6, CYP1A2 and P-glycoprotein and accelerates the clearance of irinotecan. The result is altered irinotecan and SN-38 disposition, with reduced exposure and possible loss of efficacy.
用白話說明這項交互作用的意義
Carbamazepine and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Irinotecan belongs to Oncology.
為什麼會發生
Enzyme induction by carbamazepine increases metabolic clearance of irinotecan
處置方式
Avoid where possible by choosing a non-inducing alternative; if unavoidable, monitor clinical response (and drug levels where available) and consider a higher irinotecan dose only per specialist advice.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Carbamazepine 的其他交互作用
Irinotecan 的其他交互作用
常見問題
Can I take Carbamazepine with Irinotecan?
MediHelp rates the interaction as major. Carbamazepine and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine is a strong inducer of CYP3A4, CYP2B6, CYP1A2 and P-glycoprotein and accelerates the clearance of irinotecan. The result is altered irinotecan and SN-38 disposition, with reduced exposure and possible loss of efficacy.
How serious is the interaction between Carbamazepine and Irinotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible by choosing a non-inducing alternative; if unavoidable, monitor clinical response (and drug levels where available) and consider a higher irinotecan dose only per specialist advice.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
