藥物交互作用
Adenovirus types 4 and 7 live + Topotecan
嚴重程度: 禁忌併用
Adenovirus types 4 and 7 live and Topotecan: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Topotecan causes myelosuppression and immunosuppression, so a live oral adenovirus vaccine may replicate excessively and cause infection. The vaccine response may also be inadequate.
用白話說明這項交互作用的意義
Adenovirus types 4 and 7 live and Topotecan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Cytotoxic immunosuppression impairs control of live attenuated virus replication and blunts vaccine-induced immunity.
處置方式
Do not give live vaccines during chemotherapy. Defer vaccination until immune recovery, typically at least 3 months after stopping treatment, and consider non-live alternatives.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Topotecan 的其他交互作用
常見問題
Can I take Adenovirus types 4 and 7 live with Topotecan?
MediHelp rates the interaction as contraindicated. Adenovirus types 4 and 7 live and Topotecan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Topotecan causes myelosuppression and immunosuppression, so a live oral adenovirus vaccine may replicate excessively and cause infection. The vaccine response may also be inadequate.
How serious is the interaction between Adenovirus types 4 and 7 live and Topotecan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines during chemotherapy. Defer vaccination until immune recovery, typically at least 3 months after stopping treatment, and consider non-live alternatives.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Amiodarone, Cisplatin, Cobicistat. The full list is on the Topotecan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
