藥物交互作用
Cisplatin + Topotecan
嚴重程度: 嚴重
Cisplatin and Topotecan: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Cisplatin and topotecan both suppress bone marrow, and together they produce more severe neutropenia and thrombocytopenia than either drug alone. Myelosuppression can be dose-limiting and may lead to infection or bleeding.
用白話說明這項交互作用的意義
Cisplatin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Topotecan belongs to Oncology.
為什麼會發生
Additive pharmacodynamic myelosuppression, with possible sequence-dependent enhancement of toxicity.
處置方式
Monitor complete blood counts frequently and reduce topotecan dose or delay cycles for severe cytopenias. Follow established regimen sequencing and use growth factor support when indicated.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cisplatin 的其他交互作用
Topotecan 的其他交互作用
常見問題
Can I take Cisplatin with Topotecan?
MediHelp rates the interaction as major. Cisplatin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisplatin and topotecan both suppress bone marrow, and together they produce more severe neutropenia and thrombocytopenia than either drug alone. Myelosuppression can be dose-limiting and may lead to infection or bleeding.
How serious is the interaction between Cisplatin and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce topotecan dose or delay cycles for severe cytopenias. Follow established regimen sequencing and use growth factor support when indicated.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
