藥物交互作用
Cobicistat + Topotecan
嚴重程度: 嚴重
Cobicistat and Topotecan: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cobicistat inhibits P-glycoprotein and BCRP, both of which transport topotecan. Increased topotecan exposure may worsen neutropenia and other toxicities.
用白話說明這項交互作用的意義
Cobicistat and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cobicistat belongs to Miscellaneous; Topotecan belongs to Oncology.
為什麼會發生
Cobicistat inhibits P-gp and BCRP efflux of topotecan, increasing its absorption and reducing elimination.
處置方式
Avoid with oral topotecan. With IV topotecan, monitor blood counts closely and consider dose reduction.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Topotecan 的其他交互作用
Cobicistat 的其他交互作用
常見問題
Can I take Cobicistat with Topotecan?
MediHelp rates the interaction as major. Cobicistat and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat inhibits P-glycoprotein and BCRP, both of which transport topotecan. Increased topotecan exposure may worsen neutropenia and other toxicities.
How serious is the interaction between Cobicistat and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with oral topotecan. With IV topotecan, monitor blood counts closely and consider dose reduction.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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