藥物交互作用
Aldesleukin + Budesonide
嚴重程度: 嚴重
Aldesleukin and Budesonide: major interaction.
最後更新
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摘要
Corticosteroids can blunt the immune activation that underlies the antitumor activity of aldesleukin, so efficacy may be reduced. Systemic budesonide exposure is lower than that of other systemic steroids but remains relevant with oral formulations.
用白話說明這項交互作用的意義
Aldesleukin and Budesonide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aldesleukin belongs to Oncology; Budesonide belongs to Respiratory.
為什麼會發生
Pharmacodynamic antagonism: corticosteroid immunosuppression opposes interleukin-2-mediated lymphocyte activation.
處置方式
Avoid systemic corticosteroids, including oral budesonide, during aldesleukin therapy unless needed to treat life-threatening toxicity. Inhaled or topical use carries less concern.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Budesonide 的其他交互作用
Aldesleukin 的其他交互作用
常見問題
Can I take Aldesleukin with Budesonide?
MediHelp rates the interaction as major. Aldesleukin and Budesonide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Corticosteroids can blunt the immune activation that underlies the antitumor activity of aldesleukin, so efficacy may be reduced. Systemic budesonide exposure is lower than that of other systemic steroids but remains relevant with oral formulations.
How serious is the interaction between Aldesleukin and Budesonide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic corticosteroids, including oral budesonide, during aldesleukin therapy unless needed to treat life-threatening toxicity. Inhaled or topical use carries less concern.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Atazanavir, Bcg vaccine live, Ceritinib. The full list is on the Budesonide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
