藥物交互作用
Budesonide + Darunavir
嚴重程度: 嚴重
Budesonide and Darunavir: major interaction.
最後更新
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摘要
Darunavir, especially when boosted with ritonavir or cobicistat, increases systemic budesonide exposure and can lead to Cushing's syndrome and adrenal suppression. Budesonide does not meaningfully alter darunavir levels.
用白話說明這項交互作用的意義
Budesonide and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide belongs to Respiratory; Darunavir belongs to Anti Virals.
為什麼會發生
Inhibition of CYP3A4 metabolism of budesonide by darunavir and its pharmacokinetic booster.
處置方式
Avoid long-term coadministration and consider beclomethasone as an alternative. If used, monitor for Cushingoid features and adrenal suppression.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Budesonide 的其他交互作用
Darunavir 的其他交互作用
常見問題
Can I take Budesonide with Darunavir?
MediHelp rates the interaction as major. Budesonide and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, especially when boosted with ritonavir or cobicistat, increases systemic budesonide exposure and can lead to Cushing's syndrome and adrenal suppression. Budesonide does not meaningfully alter darunavir levels.
How serious is the interaction between Budesonide and Darunavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term coadministration and consider beclomethasone as an alternative. If used, monitor for Cushingoid features and adrenal suppression.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
