藥物交互作用
Atazanavir + Budesonide
嚴重程度: 嚴重
Atazanavir and Budesonide: major interaction.
最後更新
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摘要
Atazanavir, a potent CYP3A4 inhibitor boosted or not, can markedly raise systemic budesonide concentrations. This can cause iatrogenic Cushing's syndrome and adrenal suppression, even with inhaled or intranasal budesonide.
用白話說明這項交互作用的意義
Atazanavir and Budesonide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Budesonide belongs to Respiratory.
為什麼會發生
Inhibition of CYP3A4-mediated first-pass and systemic metabolism of budesonide.
處置方式
Avoid long-term combination where possible and consider an alternative corticosteroid such as beclomethasone. If combined, monitor for Cushingoid features and adrenal suppression.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Budesonide 的其他交互作用
Atazanavir 的其他交互作用
常見問題
Can I take Atazanavir with Budesonide?
MediHelp rates the interaction as major. Atazanavir and Budesonide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir, a potent CYP3A4 inhibitor boosted or not, can markedly raise systemic budesonide concentrations. This can cause iatrogenic Cushing's syndrome and adrenal suppression, even with inhaled or intranasal budesonide.
How serious is the interaction between Atazanavir and Budesonide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term combination where possible and consider an alternative corticosteroid such as beclomethasone. If combined, monitor for Cushingoid features and adrenal suppression.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Bcg vaccine live, Ceritinib. The full list is on the Budesonide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
