藥物交互作用
Alfentanil + Chlordiazepoxide-clidinium
嚴重程度: 嚴重
Alfentanil and Chlordiazepoxide-clidinium: major interaction.
最後更新
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摘要
Combining a benzodiazepine with an opioid such as alfentanil increases sedation and the risk of respiratory depression, coma and death.
用白話說明這項交互作用的意義
Alfentanil and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression.
處置方式
Avoid unless necessary; use the lowest doses and shortest duration with continuous monitoring of respiratory status and sedation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlordiazepoxide-clidinium 的其他交互作用
常見問題
Can I take Alfentanil with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Alfentanil and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a benzodiazepine with an opioid such as alfentanil increases sedation and the risk of respiratory depression, coma and death.
How serious is the interaction between Alfentanil and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless necessary; use the lowest doses and shortest duration with continuous monitoring of respiratory status and sedation.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Chlordiazepoxide-clidinium page.
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