藥物交互作用
Brexanolone + Chlordiazepoxide-clidinium
嚴重程度: 嚴重
Brexanolone and Chlordiazepoxide-clidinium: major interaction.
最後更新
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摘要
Brexanolone causes excessive sedation and sudden loss of consciousness, and benzodiazepines may add to these effects.
用白話說明這項交互作用的意義
Brexanolone and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive GABA-A receptor-mediated CNS depression.
處置方式
Monitor continuously for sedation and hypoxia during infusion. Interrupt or reduce the infusion if excessive sedation occurs, and consider holding the benzodiazepine.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlordiazepoxide-clidinium 的其他交互作用
常見問題
Can I take Brexanolone with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Brexanolone and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone causes excessive sedation and sudden loss of consciousness, and benzodiazepines may add to these effects.
How serious is the interaction between Brexanolone and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor continuously for sedation and hypoxia during infusion. Interrupt or reduce the infusion if excessive sedation occurs, and consider holding the benzodiazepine.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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