藥物交互作用
Alprazolam + Chlordiazepoxide-clidinium
嚴重程度: 嚴重
Alprazolam and Chlordiazepoxide-clidinium: major interaction.
最後更新
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摘要
Combining two benzodiazepines duplicates therapy and increases sedation, psychomotor impairment, falls and respiratory depression risk. There is no therapeutic advantage to the combination in most patients.
用白話說明這項交互作用的意義
Alprazolam and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alprazolam belongs to Central Nervous System; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.
為什麼會發生
Additive GABA-A receptor mediated CNS and respiratory depression.
處置方式
Avoid concurrent use of two benzodiazepines and consolidate to a single agent. If unavoidable, use the lowest doses for the shortest time and monitor sedation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlordiazepoxide-clidinium 的其他交互作用
Alprazolam 的其他交互作用
常見問題
Can I take Alprazolam with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Alprazolam and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two benzodiazepines duplicates therapy and increases sedation, psychomotor impairment, falls and respiratory depression risk. There is no therapeutic advantage to the combination in most patients.
How serious is the interaction between Alprazolam and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two benzodiazepines and consolidate to a single agent. If unavoidable, use the lowest doses for the shortest time and monitor sedation.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Chlordiazepoxide-clidinium page.
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