藥物交互作用
Alfentanil + Codeine
嚴重程度: 嚴重
Alfentanil and Codeine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both are opioid agonists, so combined use increases sedation, respiratory depression and hypotension. The risk is highest with higher doses or in opioid-naive or elderly patients.
用白話說明這項交互作用的意義
Alfentanil and Codeine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive mu-opioid receptor mediated CNS and respiratory depression.
處置方式
Avoid unplanned combinations; if used, lower doses and monitor respiratory rate and sedation closely. Ensure naloxone and ventilatory support are available in procedural settings.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Codeine 的其他交互作用
常見問題
Can I take Alfentanil with Codeine?
MediHelp rates the interaction as major. Alfentanil and Codeine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are opioid agonists, so combined use increases sedation, respiratory depression and hypotension. The risk is highest with higher doses or in opioid-naive or elderly patients.
How serious is the interaction between Alfentanil and Codeine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unplanned combinations; if used, lower doses and monitor respiratory rate and sedation closely. Ensure naloxone and ventilatory support are available in procedural settings.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
