藥物交互作用
Codeine + Olanzapine / samidorphan
嚴重程度: 禁忌併用
Codeine and Olanzapine / samidorphan: contraindicated interaction.
最後更新
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摘要
Samidorphan blocks opioid receptors, reducing codeine analgesia and potentially precipitating withdrawal in dependent patients. Higher opioid doses to override the blockade risk overdose.
用白話說明這項交互作用的意義
Codeine and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Samidorphan is a mu-opioid receptor antagonist that opposes the effects of opioid agonists.
處置方式
Allow an opioid-free interval of at least 7 days before starting olanzapine/samidorphan. Choose a different antipsychotic if opioids are needed.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Codeine 的其他交互作用
常見問題
Can I take Codeine with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Codeine and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan blocks opioid receptors, reducing codeine analgesia and potentially precipitating withdrawal in dependent patients. Higher opioid doses to override the blockade risk overdose.
How serious is the interaction between Codeine and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Allow an opioid-free interval of at least 7 days before starting olanzapine/samidorphan. Choose a different antipsychotic if opioids are needed.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Phenelzine. The full list is on the Codeine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
