藥物交互作用
Codeine + Isocarboxazid
嚴重程度: 禁忌併用
Codeine and Isocarboxazid: contraindicated interaction.
最後更新
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摘要
MAO inhibitors given with opioids have caused severe reactions including serotonin syndrome-like excitation, hypertension or hypotension, hyperpyrexia and coma. Codeine labeling advises against use during or shortly after MAOI therapy.
用白話說明這項交互作用的意義
Codeine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Codeine belongs to Musculoskeletal; Isocarboxazid belongs to Central Nervous System.
為什麼會發生
MAO inhibition increases monoamine levels and potentiates opioid effects, with an incompletely understood mechanism.
處置方式
Do not use codeine with isocarboxazid or within 14 days of stopping an MAOI. Choose a non-opioid or alternative analgesic.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Codeine 的其他交互作用
Isocarboxazid 的其他交互作用
常見問題
Can I take Codeine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Codeine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors given with opioids have caused severe reactions including serotonin syndrome-like excitation, hypertension or hypotension, hyperpyrexia and coma. Codeine labeling advises against use during or shortly after MAOI therapy.
How serious is the interaction between Codeine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use codeine with isocarboxazid or within 14 days of stopping an MAOI. Choose a non-opioid or alternative analgesic.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Olanzapine / samidorphan, Phenelzine. The full list is on the Codeine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
