藥物交互作用
Codeine + Phenelzine
嚴重程度: 禁忌併用
Codeine and Phenelzine: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Phenelzine, a nonselective MAOI, taken with codeine can cause serotonin syndrome or an opioid-MAOI reaction with hypertension or hypotension, hyperthermia, agitation, coma and respiratory depression. The reaction can be severe.
用白話說明這項交互作用的意義
Codeine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Codeine belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.
為什麼會發生
Irreversible MAO inhibition combined with opioid serotonergic and CNS depressant effects produces serotonin toxicity and exaggerated opioid effects.
處置方式
Do not use codeine during or within 14 days after stopping phenelzine. Choose a non-serotonergic analgesic instead.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Codeine 的其他交互作用
Phenelzine 的其他交互作用
常見問題
Can I take Codeine with Phenelzine?
MediHelp rates the interaction as contraindicated. Codeine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine, a nonselective MAOI, taken with codeine can cause serotonin syndrome or an opioid-MAOI reaction with hypertension or hypotension, hyperthermia, agitation, coma and respiratory depression. The reaction can be severe.
How serious is the interaction between Codeine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use codeine during or within 14 days after stopping phenelzine. Choose a non-serotonergic analgesic instead.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
