藥物交互作用
Aliskiren + Losartan
嚴重程度: 禁忌併用
Aliskiren and Losartan: contraindicated interaction.
最後更新
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摘要
Combining an angiotensin receptor blocker with aliskiren produces dual renin-angiotensin blockade. This raises the risk of hypotension, hyperkalemia and renal impairment, including acute kidney injury, without added outcome benefit. The combination is contraindicated in patients with diabetes and should be avoided in renal impairment.
用白話說明這項交互作用的意義
Aliskiren and Losartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Aliskiren belongs to Cardiovascular; Losartan belongs to Cardiovascular.
為什麼會發生
Additive pharmacodynamic blockade of the renin-angiotensin-aldosterone system at two different points.
處置方式
Do not co-prescribe in patients with diabetes or with GFR below 60 mL/min; avoid in others where possible. If ever used, monitor blood pressure, potassium and creatinine closely.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Losartan 的其他交互作用
Aliskiren 的其他交互作用
常見問題
Can I take Aliskiren with Losartan?
MediHelp rates the interaction as contraindicated. Aliskiren and Losartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an angiotensin receptor blocker with aliskiren produces dual renin-angiotensin blockade. This raises the risk of hypotension, hyperkalemia and renal impairment, including acute kidney injury, without added outcome benefit. The combination is contraindicated in patients with diabetes and should be avoided in renal impairment.
How serious is the interaction between Aliskiren and Losartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe in patients with diabetes or with GFR below 60 mL/min; avoid in others where possible. If ever used, monitor blood pressure, potassium and creatinine closely.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Sparsentan, Amifostine, Amiloride. The full list is on the Losartan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
