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藥物交互作用

Amlodipine-hydrochlorothiazide-valsartan + Losartan

嚴重程度: 嚴重

Amlodipine-hydrochlorothiazide-valsartan and Losartan: major interaction.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Combining two angiotensin receptor blockers (valsartan plus losartan) gives no added benefit and increases the risk of hypotension, hyperkalemia, and renal impairment.

用白話說明這項交互作用的意義

Amlodipine-hydrochlorothiazide-valsartan and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Losartan belongs to Cardiovascular.

證據等級: High

為什麼會發生

Duplicate angiotensin II type 1 receptor blockade produces additive hypotension, reduced aldosterone effect, and reduced glomerular filtration.

處置方式

Avoid using two ARBs together; keep a single agent. If both were taken, stop one and check serum potassium and creatinine.

可向藥師詢問的問題

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Amlodipine-hydrochlorothiazide-valsartan with Losartan?

MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two angiotensin receptor blockers (valsartan plus losartan) gives no added benefit and increases the risk of hypotension, hyperkalemia, and renal impairment.

How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Losartan?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two ARBs together; keep a single agent. If both were taken, stop one and check serum potassium and creatinine.

What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?

MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.

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