藥物交互作用
Amiloride + Losartan
嚴重程度: 嚴重
Amiloride and Losartan: major interaction.
最後更新 來源: US FDA label
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摘要
Angiotensin receptor blockers reduce aldosterone and, with amiloride, markedly raise the risk of hyperkalemia. Severe hyperkalemia can cause dangerous arrhythmias, particularly with renal impairment or diabetes.
用白話說明這項交互作用的意義
Amiloride and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Losartan belongs to Cardiovascular.
為什麼會發生
ARB-induced aldosterone suppression and amiloride's epithelial sodium channel blockade both reduce renal potassium excretion.
處置方式
Avoid routine combination; if used, check potassium and creatinine within the first week and regularly afterwards, starting amiloride at a low dose.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Amiloride 的其他交互作用
Losartan 的其他交互作用
常見問題
Can I take Amiloride with Losartan?
MediHelp rates the interaction as major. Amiloride and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Angiotensin receptor blockers reduce aldosterone and, with amiloride, markedly raise the risk of hyperkalemia. Severe hyperkalemia can cause dangerous arrhythmias, particularly with renal impairment or diabetes.
How serious is the interaction between Amiloride and Losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination; if used, check potassium and creatinine within the first week and regularly afterwards, starting amiloride at a low dose.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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