藥物交互作用
Amlodipine-olmesartan-hydrochlorothiazide + Losartan
嚴重程度: 嚴重
Amlodipine-olmesartan-hydrochlorothiazide and Losartan: major interaction.
最後更新
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摘要
Combining losartan with a product that already contains olmesartan means two angiotensin receptor blockers are used together. This gives no meaningful added benefit and increases the risk of hypotension, hyperkalemia and renal impairment.
用白話說明這項交互作用的意義
Amlodipine-olmesartan-hydrochlorothiazide and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Losartan belongs to Cardiovascular.
為什麼會發生
Duplicate angiotensin II type 1 receptor blockade produces additive hypotensive, renal and potassium-retaining effects.
處置方式
Avoid concurrent use of two angiotensin receptor blockers and discontinue one of them. If an overlap occurs, check blood pressure, serum potassium and creatinine.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amlodipine-olmesartan-hydrochlorothiazide 的其他交互作用
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide 禁忌併用
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide 禁忌併用
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan 禁忌併用
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
Losartan 的其他交互作用
常見問題
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Losartan?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining losartan with a product that already contains olmesartan means two angiotensin receptor blockers are used together. This gives no meaningful added benefit and increases the risk of hypotension, hyperkalemia and renal impairment.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two angiotensin receptor blockers and discontinue one of them. If an overlap occurs, check blood pressure, serum potassium and creatinine.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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