藥物交互作用
Alogliptin-metformin + Entecavir
嚴重程度: 中度
Alogliptin-metformin and Entecavir: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Entecavir, a nucleoside analogue, has been associated with lactic acidosis and severe hepatomegaly with steatosis. Metformin carries its own risk of lactic acidosis, so using both may add to that risk, particularly in patients with renal or hepatic impairment.
用白話說明這項交互作用的意義
Alogliptin-metformin and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-metformin belongs to Endocrine; Entecavir belongs to Anti Virals.
為什麼會發生
Additive risk of lactic acidosis through mitochondrial toxicity (entecavir) and impaired lactate clearance (metformin); no direct pharmacokinetic interaction is established.
處置方式
Monitor renal and hepatic function periodically and educate the patient to report nausea, abdominal pain, malaise or rapid breathing. Check lactate and stop metformin if lactic acidosis is suspected.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Alogliptin-metformin 的其他交互作用
Entecavir 的其他交互作用
常見問題
Can I take Alogliptin-metformin with Entecavir?
MediHelp rates the interaction as moderate. Alogliptin-metformin and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entecavir, a nucleoside analogue, has been associated with lactic acidosis and severe hepatomegaly with steatosis. Metformin carries its own risk of lactic acidosis, so using both may add to that risk, particularly in patients with renal or hepatic impairment.
How serious is the interaction between Alogliptin-metformin and Entecavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal and hepatic function periodically and educate the patient to report nausea, abdominal pain, malaise or rapid breathing. Check lactate and stop metformin if lactic acidosis is suspected.
What other medicines interact with Alogliptin-metformin?
MediHelp also lists interactions of Alogliptin-metformin with, for example, Clozapine, Contrast media, Diatrizoate. The full list is on the Alogliptin-metformin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
