藥物交互作用
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Entecavir
嚴重程度: 中度
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Entecavir: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Entecavir, emtricitabine and tenofovir are all eliminated by the kidney through filtration and active tubular secretion, and cobicistat can raise serum creatinine by inhibiting tubular secretion. Concurrent use may increase concentrations of the renally cleared drugs and the risk of renal adverse events. Entecavir is sometimes combined with tenofovir regimens in hepatitis B coinfection.
用白話說明這項交互作用的意義
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Competition for renal tubular secretion and additive renal burden, which can decrease clearance of each drug.
處置方式
Monitor serum creatinine, estimated clearance and phosphate regularly. Adjust the entecavir dose if creatinine clearance falls.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Entecavir 的其他交互作用
常見問題
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Entecavir?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entecavir, emtricitabine and tenofovir are all eliminated by the kidney through filtration and active tubular secretion, and cobicistat can raise serum creatinine by inhibiting tubular secretion. Concurrent use may increase concentrations of the renally cleared drugs and the risk of renal adverse events. Entecavir is sometimes combined with tenofovir regimens in hepatitis B coinfection.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Entecavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, estimated clearance and phosphate regularly. Adjust the entecavir dose if creatinine clearance falls.
What other medicines interact with Entecavir?
MediHelp also lists interactions of Entecavir with, for example, Alogliptin-metformin, Canagliflozin-metformin, Cidofovir. The full list is on the Entecavir page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
