藥物交互作用
Alprazolam + Morphine
嚴重程度: 嚴重
Alprazolam and Morphine: major interaction.
最後更新
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摘要
Combining an opioid with a benzodiazepine can cause profound sedation, respiratory depression, coma and death. Regulators have issued boxed warnings against concomitant use unless alternatives are inadequate.
用白話說明這項交互作用的意義
Alprazolam and Morphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alprazolam belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
為什麼會發生
Additive CNS and respiratory depression through opioid receptor and GABA-A receptor activity.
處置方式
Avoid the combination if possible; otherwise use the lowest doses and shortest duration, and monitor closely for sedation and respiratory depression. Counsel patients and caregivers about warning signs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Morphine 的其他交互作用
Alprazolam 的其他交互作用
常見問題
Can I take Alprazolam with Morphine?
MediHelp rates the interaction as major. Alprazolam and Morphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a benzodiazepine can cause profound sedation, respiratory depression, coma and death. Regulators have issued boxed warnings against concomitant use unless alternatives are inadequate.
How serious is the interaction between Alprazolam and Morphine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise use the lowest doses and shortest duration, and monitor closely for sedation and respiratory depression. Counsel patients and caregivers about warning signs.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
