藥物交互作用
Morphine + Tranylcypromine
嚴重程度: 禁忌併用
Morphine and Tranylcypromine: contraindicated interaction.
最後更新
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摘要
Opioids with non-selective MAO inhibitors may cause serotonin syndrome or severe CNS depression, hypotension and hyperpyrexia. Morphine labeling advises against its use with MAOIs or within 14 days of stopping them.
用白話說明這項交互作用的意義
Morphine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Morphine belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.
為什麼會發生
Irreversible MAO inhibition potentiates serotonergic and CNS depressant effects of the opioid.
處置方式
Avoid morphine during tranylcypromine therapy and for 14 days afterward; use non-opioid alternatives. If unavoidable, give under close specialist monitoring.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Morphine 的其他交互作用
Tranylcypromine 的其他交互作用
常見問題
Can I take Morphine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Morphine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids with non-selective MAO inhibitors may cause serotonin syndrome or severe CNS depression, hypotension and hyperpyrexia. Morphine labeling advises against its use with MAOIs or within 14 days of stopping them.
How serious is the interaction between Morphine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid morphine during tranylcypromine therapy and for 14 days afterward; use non-opioid alternatives. If unavoidable, give under close specialist monitoring.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
