藥物交互作用
Alvimopan + Morphine
嚴重程度: 禁忌併用
Alvimopan and Morphine: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Alvimopan is a peripherally acting mu-opioid antagonist, and patients who have taken opioids for more than a week before starting it are more sensitive to its effects. They may develop abdominal pain, nausea, vomiting and diarrhea. Short-term opioid exposure, as in the postoperative setting, is the intended use.
用白話說明這項交互作用的意義
Alvimopan and Morphine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Competitive antagonism at peripheral gastrointestinal mu-opioid receptors in opioid-tolerant patients.
處置方式
Do not give alvimopan to patients who have received therapeutic opioid doses for more than 7 consecutive days before it. Limit use to short-term perioperative opioid exposure.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Morphine 的其他交互作用
常見問題
Can I take Alvimopan with Morphine?
MediHelp rates the interaction as contraindicated. Alvimopan and Morphine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Alvimopan is a peripherally acting mu-opioid antagonist, and patients who have taken opioids for more than a week before starting it are more sensitive to its effects. They may develop abdominal pain, nausea, vomiting and diarrhea. Short-term opioid exposure, as in the postoperative setting, is the intended use.
How serious is the interaction between Alvimopan and Morphine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give alvimopan to patients who have received therapeutic opioid doses for more than 7 consecutive days before it. Limit use to short-term perioperative opioid exposure.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Morphine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
