藥物交互作用
Morphine + Olanzapine / samidorphan
嚴重程度: 禁忌併用
Morphine and Olanzapine / samidorphan: contraindicated interaction.
最後更新
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摘要
Samidorphan is an opioid antagonist that blocks morphine's effect and can precipitate acute withdrawal in opioid-dependent patients. Patients on opioids who start the combination may also have reduced analgesia.
用白話說明這項交互作用的意義
Morphine and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Pharmacodynamic antagonism at opioid receptors by samidorphan.
處置方式
Do not start in patients using opioids; ensure an opioid-free interval of at least 7 days for short-acting opioids before starting. Use an alternative antipsychotic if opioids are required.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Morphine 的其他交互作用
常見問題
Can I take Morphine with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Morphine and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan is an opioid antagonist that blocks morphine's effect and can precipitate acute withdrawal in opioid-dependent patients. Patients on opioids who start the combination may also have reduced analgesia.
How serious is the interaction between Morphine and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not start in patients using opioids; ensure an opioid-free interval of at least 7 days for short-acting opioids before starting. Use an alternative antipsychotic if opioids are required.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Phenelzine. The full list is on the Morphine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
