藥物交互作用
Aluminum hydroxide + Cefpodoxime
嚴重程度: 中度
Aluminum hydroxide and Cefpodoxime: moderate interaction.
最後更新
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摘要
Antacids that raise gastric pH reduce the dissolution and absorption of cefpodoxime proxetil. This can lower peak concentrations and total exposure and may reduce antibacterial efficacy.
用白話說明這項交互作用的意義
Aluminum hydroxide and Cefpodoxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Cefpodoxime belongs to Anti Bacterial.
為什麼會發生
Higher gastric pH impairs dissolution of cefpodoxime proxetil, which depends on an acidic environment, and so reduces its absorption.
處置方式
Give cefpodoxime at least 2 hours before or after the aluminum hydroxide antacid. If acid suppression is needed continuously, consider another cephalosporin or monitor clinical response.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Aluminum hydroxide 的其他交互作用
Cefpodoxime 的其他交互作用
常見問題
Can I take Aluminum hydroxide with Cefpodoxime?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Cefpodoxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids that raise gastric pH reduce the dissolution and absorption of cefpodoxime proxetil. This can lower peak concentrations and total exposure and may reduce antibacterial efficacy.
How serious is the interaction between Aluminum hydroxide and Cefpodoxime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give cefpodoxime at least 2 hours before or after the aluminum hydroxide antacid. If acid suppression is needed continuously, consider another cephalosporin or monitor clinical response.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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