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藥物交互作用

Cefpodoxime + Cimetidine

嚴重程度: 中度

Cefpodoxime and Cimetidine: moderate interaction.

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僅供醫療專業人員參考。本頁為簡要摘要,並非醫療建議,亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

H2 blockers lower the oral absorption of cefpodoxime proxetil. Lower antibiotic levels may reduce efficacy.

用白話說明這項交互作用的意義

Cefpodoxime and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cefpodoxime belongs to Anti Bacterial; Cimetidine belongs to Gastrointestinal Tract.

證據等級: Moderate

為什麼會發生

Increased gastric pH reduces dissolution and absorption of cefpodoxime proxetil.

處置方式

Prefer an alternative antibiotic or stop the acid suppressant if possible. Take cefpodoxime with food to improve absorption and monitor response.

可向藥師詢問的問題

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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  • Evidence detail
  • Interaction checker for a whole prescription

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常見問題

Can I take Cefpodoxime with Cimetidine?

MediHelp rates the interaction as moderate. Cefpodoxime and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. H2 blockers lower the oral absorption of cefpodoxime proxetil. Lower antibiotic levels may reduce efficacy.

How serious is the interaction between Cefpodoxime and Cimetidine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic or stop the acid suppressant if possible. Take cefpodoxime with food to improve absorption and monitor response.

What other medicines interact with Cimetidine?

MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.

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