藥物交互作用
Amifampridine + Meropenem
嚴重程度: 中度
Amifampridine and Meropenem: moderate interaction.
最後更新
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摘要
Both drugs can lower the seizure threshold, and carbapenems such as meropenem have been associated with seizures, particularly in renal impairment or CNS disease. Combining them may raise the risk of seizures in patients taking amifampridine.
用白話說明這項交互作用的意義
Amifampridine and Meropenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Meropenem belongs to Anti Bacterial.
為什麼會發生
Additive pharmacodynamic lowering of the seizure threshold.
處置方式
Consider an alternative antibiotic with lower seizure liability in patients with a seizure history or renal impairment. If combined, adjust meropenem for renal function and monitor for neurological signs.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Meropenem 的其他交互作用
Amifampridine 的其他交互作用
常見問題
Can I take Amifampridine with Meropenem?
MediHelp rates the interaction as moderate. Amifampridine and Meropenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower the seizure threshold, and carbapenems such as meropenem have been associated with seizures, particularly in renal impairment or CNS disease. Combining them may raise the risk of seizures in patients taking amifampridine.
How serious is the interaction between Amifampridine and Meropenem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic with lower seizure liability in patients with a seizure history or renal impairment. If combined, adjust meropenem for renal function and monitor for neurological signs.
What other medicines interact with Meropenem?
MediHelp also lists interactions of Meropenem with, for example, Valproic acid, Typhoid vaccine live, Cholera vaccine. The full list is on the Meropenem page.
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