藥物交互作用
Meropenem + Probenecid
嚴重程度: 中度
Meropenem and Probenecid: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Probenecid inhibits renal tubular secretion of meropenem, increasing its half-life and exposure. Labeling advises against the combination because the benefit is not established.
用白話說明這項交互作用的意義
Meropenem and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meropenem belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
為什麼會發生
Probenecid competes for renal tubular organic anion transport of meropenem.
處置方式
Avoid coadministration where possible. If used together, monitor for adverse effects including seizures in patients with renal impairment.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Probenecid 的其他交互作用
Meropenem 的其他交互作用
常見問題
Can I take Meropenem with Probenecid?
MediHelp rates the interaction as moderate. Meropenem and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid inhibits renal tubular secretion of meropenem, increasing its half-life and exposure. Labeling advises against the combination because the benefit is not established.
How serious is the interaction between Meropenem and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible. If used together, monitor for adverse effects including seizures in patients with renal impairment.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
