藥物交互作用
Amikacin + Rocuronium
嚴重程度: 嚴重
Amikacin and Rocuronium: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Amikacin can intensify and prolong neuromuscular blockade from rocuronium. This may lead to delayed recovery, respiratory depression or apnea, especially in renal impairment.
用白話說明這項交互作用的意義
Amikacin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amikacin belongs to Anti Bacterial; Rocuronium belongs to Musculoskeletal.
為什麼會發生
Aminoglycosides inhibit presynaptic acetylcholine release and reduce postsynaptic sensitivity, adding to competitive nicotinic blockade.
處置方式
Monitor with train-of-four and reduce rocuronium dosing as needed. Keep ventilatory support available until full recovery is confirmed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Rocuronium 的其他交互作用
Amikacin 的其他交互作用
常見問題
Can I take Amikacin with Rocuronium?
MediHelp rates the interaction as major. Amikacin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amikacin can intensify and prolong neuromuscular blockade from rocuronium. This may lead to delayed recovery, respiratory depression or apnea, especially in renal impairment.
How serious is the interaction between Amikacin and Rocuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor with train-of-four and reduce rocuronium dosing as needed. Keep ventilatory support available until full recovery is confirmed.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Bacitracin-neomycin-polymyxin, Capreomycin, Clindamycin. The full list is on the Rocuronium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
