藥物交互作用
Dexamethasone-tobramycin + Rocuronium
嚴重程度: 嚴重
Dexamethasone-tobramycin and Rocuronium: major interaction.
最後更新
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摘要
Aminoglycosides such as tobramycin can potentiate non-depolarizing neuromuscular blockers, causing prolonged paralysis and respiratory depression. This matters mainly with systemic tobramycin.
用白話說明這項交互作用的意義
Dexamethasone-tobramycin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-tobramycin belongs to Anti Bacterial; Rocuronium belongs to Musculoskeletal.
為什麼會發生
Tobramycin impairs acetylcholine release and neuromuscular transmission, adding to the blockade.
處置方式
Monitor neuromuscular function with train-of-four and adjust rocuronium dosing; be ready to provide ventilatory support postoperatively.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dexamethasone-tobramycin 的其他交互作用
Rocuronium 的其他交互作用
常見問題
Can I take Dexamethasone-tobramycin with Rocuronium?
MediHelp rates the interaction as major. Dexamethasone-tobramycin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides such as tobramycin can potentiate non-depolarizing neuromuscular blockers, causing prolonged paralysis and respiratory depression. This matters mainly with systemic tobramycin.
How serious is the interaction between Dexamethasone-tobramycin and Rocuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and adjust rocuronium dosing; be ready to provide ventilatory support postoperatively.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
