藥物交互作用
Bacitracin-neomycin-polymyxin + Rocuronium
嚴重程度: 嚴重
Bacitracin-neomycin-polymyxin and Rocuronium: major interaction.
最後更新
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摘要
Polymyxin B and neomycin can potentiate rocuronium's neuromuscular blockade. This may prolong paralysis and delay recovery of spontaneous breathing. The risk is mainly with systemic or irrigation use, not small topical areas.
用白話說明這項交互作用的意義
Bacitracin-neomycin-polymyxin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacitracin-neomycin-polymyxin belongs to Anti Bacterial; Rocuronium belongs to Musculoskeletal.
為什麼會發生
Additive pharmacodynamic neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic receptor effects.
處置方式
Avoid systemic, irrigation or large-area combination antibiotic exposure during neuromuscular blockade where possible. If used, monitor neuromuscular function with train-of-four and ensure ventilatory support is available.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bacitracin-neomycin-polymyxin 的其他交互作用
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin 嚴重
- Atracurium + Bacitracin-neomycin-polymyxin 嚴重
- Bacitracin-neomycin-polymyxin + Capreomycin 嚴重
- Bacitracin-neomycin-polymyxin + Cidofovir 嚴重
- Bacitracin-neomycin-polymyxin + Cisatracurium 嚴重
- Bacitracin-neomycin-polymyxin + Pancuronium 嚴重
Rocuronium 的其他交互作用
常見問題
Can I take Bacitracin-neomycin-polymyxin with Rocuronium?
MediHelp rates the interaction as major. Bacitracin-neomycin-polymyxin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Polymyxin B and neomycin can potentiate rocuronium's neuromuscular blockade. This may prolong paralysis and delay recovery of spontaneous breathing. The risk is mainly with systemic or irrigation use, not small topical areas.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Rocuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic, irrigation or large-area combination antibiotic exposure during neuromuscular blockade where possible. If used, monitor neuromuscular function with train-of-four and ensure ventilatory support is available.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
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在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
